Report Code : CVMI2501136 | Published Date : March 3, 2025

The Global Liver Preservation Systems Market is undergoing a technological renaissance, driven by critical organ shortages, advancements in perfusion technology, and a growing demand for transplantable organs. Valued at USD 230 million in 2023, the market is projected to grow at a CAGR of 9.8%, reaching USD 480 million by 2031. This comprehensive analysis examines the paradigm shift from static cold storage to dynamic preservation methods that significantly improve transplant outcomes and expand the donor pool.

Three key trends are reshaping the market: the validation of normothermic perfusion systems, the development of organ repair technologies during preservation, and the use of AI-driven viability assessment tools. The report highlights comparisons of preservation techniques, clinical outcomes, and the economic effects of extended preservation times. It also focuses on the growing use of marginal donor organs and the expedited regulatory pathways for new preservation systems.

2. Market Overview

2.1 Market Definition & Scope

Liver preservation systems encompass technologies that maintain organ viability between procurement and transplantation:

  • Static Cold Storage (SCS) (XX% market share)
    • Traditional ice storage
    • Hypothermic solutions
  • Machine Perfusion Systems (XX%)
    • Hypothermic perfusion
    • Normothermic perfusion
    • Subnormothermic perfusion

Key application segments:

  • Transplant Centers (XX%)
  • Organ Procurement Organizations (25%)
  • Research Institutions (XX%)

2.2 Market Size & Forecast (2023-2031)

  • 2023 Market Size: USD 230 Million
  • 2031 Projected Size: USD 480 Million
  • CAGR: 9.8%
  • Annual Liver Transplants: 40,000 (2023) → 65,000 (2031)

2.3 Key Market Segments

By Preservation Technique:

  1. Static Cold Storage (XX% share)
    • University of Wisconsin solution (XX%)
    • Histidine-Tryptophan-Ketoglutarate (HTK) (XX%)
    • Other solutions (20%)
  2. Machine Perfusion (XX%)
    • Hypothermic (50%)
    • Normothermic (XX%)
    • Subnormothermic (XX%)

By Organ Quality:

  • Standard Criteria Donors (XX%)
  • Extended Criteria Donors (XX%)

By Region:

  • North America (45%)
  • Europe (XX%)
  • Asia-Pacific (XX%)
  • Rest of World (XX%)

3. Market Dynamics

3.1 Market Drivers

1. Critical Organ Shortage

  • 20 patients die daily awaiting liver transplants (U.S.)
  • Extended criteria donors now 40% of transplants

2. Superior Clinical Outcomes

  • 50% lower early allograft dysfunction
  • 30% improved 1-year graft survival with perfusion

3. Regulatory Support

  • FDA Breakthrough Device designations
  • EU MDR creating standardized protocols

4. Technological Convergence

  • Ex vivo liver repair during perfusion
  • AI viability scoring systems

3.2 Market Challenges

1. High System Costs

  • USD 250,000 average perfusion device cost
  • Limited reimbursement pathways

2. Operational Complexity

  • Specialized training requirements
  • Logistical challenges in transport

3. Evidence Generation

  • Long-term outcome data still emerging
  • Comparative effectiveness studies needed

3.3 Market Trends

1. Portable Perfusion Systems

  • Compact designs for air transport
  • Battery-powered operation

2. Organ Repair Technologies

  • Stem cell infusion during perfusion
  • Gene therapy delivery

3. Viability Biomarkers

  • Real-time metabolite monitoring
  • Machine learning prediction algorithms

4. Competitive Landscape

4.1 Market Share Analysis

Company

Market Share

Key Products

Strategic Focus

TransMedics

30%

OCS Liver System

Normothermic leadership

OrganOx

25%

metra Device

Clinical evidence generation

Bridge to Life

20%

VitaSmart System

Hypothermic solutions

XVIVO Perfusion

15%

XPS System

Portable technology

Paragonix

10%

LIVERguard

Cold storage innovation

4.2 Emerging Players

  • Organ Assist: Modular perfusion (40% growth)
  • Liver4Life: Ex vivo repair technology
  • Preservation Solutions: Next-gen cold storage

4.3 Recent Developments (2024)

  • TransMedics FDA approval for DCD liver preservation
  • OrganOx published 5-year outcome data
  • XVIVO launched next-gen portable system

5. Regional Analysis

5.1 North America (XX%)

  • US dominates with 80% regional share
  • Canada implementing national perfusion protocols

5.2 Europe (XX%)

  • UK/Germany leading clinical adoption
  • EU funding for preservation research

5.3 Asia-Pacific (15%)

  • China fastest-growing at 12% CAGR
  • India expanding transplant infrastructure

6. Future Outlook

6.1 Short-Term Projections (2025)

  • 50% market share for perfusion systems
  • First commercial liver repair systems

6.2 Medium-Term Outlook (2027)

  • Standard of care for marginal organs
  • Automated viability assessment

6.3 Long-Term Forecast (2031)

  • 7-day preservation becoming possible
  • Widespread adoption of repair technologies




Reasons To Buy

Image



Scope

Image

Key Players

  • XVIVO Perfusion AB
  • OrganOx Limited
  • TransMedics Inc.
  • Bridge to Life Ltd.
  • Paragonix Technologies Inc.

 

Global Liver Preservation Systems Market Report

  1. 1. Global Liver Preservation Systems Market Research Report
    1. 1.1 Study Objectives
    2. 1.2 Global Liver Preservation Systems Market - Overview
    3. 1.3 Reason to Read This Report
    4. 1.4 Methodology and Forecast Analysis
    2. Global Liver Preservation Systems Market Research Report - Preface
    1. 2.1 Global Liver Preservation Systems Market Research Report – Detailed Scope and Definitions
      1. 2.1.1 By Type
      2. 2.1.2 By Application
      3. 2.1.3 By End-user
      4. 2.1.4 By Region
    3. Global Liver Preservation Systems Market Dynamics
    1. 3.1. Drivers - Macro-Economic Based, Supply Side, and Demand Side Drivers
    2. 3.2. Restraints – By Type, By Application, By End-user, By Country
    3. 3.3. Opportunities – By Type, By Application, By End-user, By Country
    4. 3.4. Trends – By Type, By Application, By End-user, By Country
    5. 3.5. PEST Analysis
    6. 3.6. Porters Five Rule Analysis
    7. 3.7. Company’s Share Analysis (CSA) by Region or By Country
    8. 3.8. Global Liver Preservation Systems Market Research Report – DROTs Impact Analysis
    4. Global Liver Preservation Systems Market Research Report, Historic Data 2019 - 2023 and Forecast Analysis Data 2024 - 2031
    1. 4.1. Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
    2. 4.2. Annual Market Trend Assessment – Year-on-Year (YoY) Growth Analysis (%)
    3. 4.3. Incremental Market Value/Volume Opportunity between 2019 - 2023 and 2024 - 2031
    4. 4.4. Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    5. Global Liver Preservation Systems Market, By Type, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 5.1 Static Cold Storage
      1. 5.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 5.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 5.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 5.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    2. 5.2 Machine Perfusion
      1. 5.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 5.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 5.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 5.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    6. Global Liver Preservation Systems Market, By Application, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 6.1 Transplantation
      1. 6.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 6.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 6.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 6.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    2. 6.2 Research
      1. 6.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 6.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 6.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 6.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    7. Global Liver Preservation Systems Market, By End-user, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 7.1 Hospitals
      1. 7.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 7.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 7.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 7.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    2. 7.2 Research Institutions
      1. 7.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 7.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 7.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 7.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    3. 7.3 Organ Procurement Organizations.
      1. 7.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 7.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 7.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 7.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    8. Global Liver Preservation Systems Market Forecast, By Region, 2019 - 2023 and 2024 - 2031 (Market Value, In USD Mn)
    1. 8.1 North America
      1. 8.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 8.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 8.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 8.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    2. 8.2 Europe
      1. 8.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 8.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 8.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 8.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    3. 8.3 Asia-Pacific
      1. 8.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 8.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 8.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 8.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    4. 8.4 Latin America
      1. 8.4.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 8.4.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 8.4.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 8.4.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    5. 8.5 Middle East & Africa
      1. 8.5.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
      2. 8.5.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
      3. 8.5.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
      4. 8.5.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
    6. 8.6 Global Liver Preservation Systems Market - Opportunity Analysis Index, By Type, By Application, By End-user, and Region, 2024 - 2031
    9. North America Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 9.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 9.1.1 Static Cold Storage
      2. 9.1.2 Machine Perfusion
      9.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 9.2.1 Transplantation
      2. 9.2.2 Research
      9.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 9.3.1 Hospitals
      2. 9.3.2 Research Institutions
      3. 9.3.3 Organ Procurement Organizations.
      9.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 9.4.1 United States
      2. 9.4.2 Canada
      9.5 North America Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
      9.6 Regional Trends Analysis
      9.7 North America Global Liver Preservation Systems Market Research Report - Company Profiles
      1. 9.7.1 Company 1 (United States)
      2. 9.7.2 Company 2 (Canada)
      3. 9.7.3 Company 3 (Canada)
    10. Europe Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 10.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 10.1.1 Static Cold Storage
      2. 10.1.2 Machine Perfusion
      10.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 10.2.1 Transplantation
      2. 10.2.2 Research
      10.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 10.3.1 Hospitals
      2. 10.3.2 Research Institutions
      3. 10.3.3 Organ Procurement Organizations.
      10.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 10.4.1 Germany
      2. 10.4.2 United Kingdom
      3. 10.4.3 France
      4. 10.4.4 Spain
      5. 10.4.5 Italy
      6. 10.4.6 Russia
      7. 10.4.7 Netherlands
      8. 10.4.8 Poland
      9. 10.4.9 Rest of Europe
      10.5 Europe Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
      10.6 Regional Trends Analysis
      10.7 Europe Global Liver Preservation Systems Market Research Report - Company Profiles
      1. 10.7.1 Company 1 (Germany)
      2. 10.7.2 Company 2 (United Kingdom)
      3. 10.7.3 Company 3 (United Kingdom)
    11. Asia-Pacific Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 11.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 11.1.1 Static Cold Storage
      2. 11.1.2 Machine Perfusion
      11.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 11.2.1 Transplantation
      2. 11.2.2 Research
      11.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 11.3.1 Hospitals
      2. 11.3.2 Research Institutions
      3. 11.3.3 Organ Procurement Organizations.
      11.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 11.4.1 China
      2. 11.4.2 Japan
      3. 11.4.3 India
      4. 11.4.4 South Korea
      5. 11.4.5 Australia & NZ
      6. 11.4.6 ASEAN
      7. 11.4.7 Rest of Asia-Pacific
      11.5 Asia-Pacific Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
      11.6 Regional Trends Analysis
      11.7 Asia-Pacific Global Liver Preservation Systems Market Research Report - Company Profiles
      1. 11.7.1 Company 1 (China)
      2. 11.7.2 Company 2 (Japan)
      3. 11.7.3 Company 3 (Japan)
    12. Latin America Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 12.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 12.1.1 Static Cold Storage
      2. 12.1.2 Machine Perfusion
      12.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 12.2.1 Transplantation
      2. 12.2.2 Research
      12.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 12.3.1 Hospitals
      2. 12.3.2 Research Institutions
      3. 12.3.3 Organ Procurement Organizations.
      12.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 12.4.1 Brazil
      2. 12.4.2 Mexico
      3. 12.4.3 Argentina
      4. 12.4.4 Peru
      5. 12.4.5 Colombia
      6. 12.4.6 Rest of Latin America
      12.5 Latin America Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
      12.6 Regional Trends Analysis
      12.7 Latin America Global Liver Preservation Systems Market Research Report - Company Profiles
      1. 12.7.1 Company 1 (Brazil)
      2. 12.7.2 Company 2 (Mexico)
      3. 12.7.3 Company 3 (Mexico)
    13. Middle East & Africa Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
    1. 13.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 13.1.1 Static Cold Storage
      2. 13.1.2 Machine Perfusion
      13.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 13.2.1 Transplantation
      2. 13.2.2 Research
      13.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 13.3.1 Hospitals
      2. 13.3.2 Research Institutions
      3. 13.3.3 Organ Procurement Organizations.
      13.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
      1. 13.4.1 Saudi Arabia
      2. 13.4.2 UAE
      3. 13.4.3 South Africa
      4. 13.4.4 Egypt
      5. 13.4.5 Israel
      6. 13.4.6 Rest of Middle East and Africa
      13.5 Middle East & Africa Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
      13.6 Regional Trends Analysis
      13.7 Middle East & Africa Global Liver Preservation Systems Market Research Report - Company Profiles
      1. 13.7.1 Company 1 (Saudi Arabia)
      2. 13.7.2 Company 2 (UAE)
      3. 13.7.3 Company 3 (UAE)
    14. Competition Landscape
    1. 14.1 Strategic Dashboard of Top Market Players
      14.2 Company Profiles (Introduction, Financial Assessments, Portfolio of Offerings, Milestones and Achievements, Strategic Initiative, and SWOT Analysis)
      1. 14.2.1 XVIVO Perfusion AB
      2. 14.2.2 OrganOx Limited
      3. 14.2.3 TransMedics Inc.
      4. 14.2.4 Bridge to Life Ltd.
      5. 14.2.5 Paragonix Technologies Inc.
    15. Data Collection Method and Research Approach
    16. Principal Presumptions and Acronyms




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